Microtubule Organizing Centers

Microtubule-organizing centers (MTOCs) mediate the nucleation of the protein tubulin into microtubules, and help organize the microtubule cytoskeleton in the cell. Animal cells contain centrioles, which contain tubulin and other proteins organized into centrosomes. During mitosis, the centrioles divide and migrate to form two poles of the mitotic spindle, important for the segregation of chromosomes. Basal bodies are a type of MTOC able to organize microtubules into the parallel arrays at the center of cilia and flagellae. Plant cells do not contain typical MTOCs, and in many plant cells the microtubules nucleate from microtubule-associated proteins that may be embedded in the nuclear envelope.

Related Molecular Functions
Related Biological Processes
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