Transmission electron micrograph of rat kidney filtration barrier. Micrograph illustrates the basement membrane between fenestrated capillary endothelium and podocyte foot processes at intermediate magnification. The series of images in this group have particular historic and cell biologic importance for determining the role of the glomerular basement membrane in urinary filtration, especially the charge properties and size selectivity in retention of proteins in the circulation. The images here clearly show the glomerular filtration barrier. The study also elucidated the role of the basement membrane in some forms of nephrosis. Image made available by James D. Jamieson and the Department of Cell Biology, Yale University School of Medicine.
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Farquhar, M.G., S.L. Wisssig and G.E. Palade. 1961 . J. Exp. Med. 113:47-66.
Original 3.25 in. x 4 in. lantern slides were scanned at 600dpi. Original magnification X19,000.