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CIL:37176*  Cite 

Transmission electron micrograph showing normal glomerulus basement membrane filtration slits 15 min post IV ferritin administration. At this time point frerritin is in the capillary lumen basement membrane and none is between the podocytes. The series of images in this group have particular historic and cell biologic importance for determining the role of the glomerular basement membrane in urinary filtration, especially the charge properties and size selectivity in retention of proteins in the circulation. The images here clearly show the glomerular filtration barrier. The study also elucidated the role of the basement membrane in some forms of nephrosis. Image made available by James D. Jamieson and the Department of Cell Biology, Yale University School of Medicine.

Technical Details

Relevant citations: Kanwar, Y.S. and M.G. Farquhar. 1979. J. Cell Biol. 81:137-153. Farquhar, M.G., S.L. Wisssig and G.E. Palade. 1961 . J. Exp. Med. 113:47-66. Original 3.25 in. x 4 in. lantern slides were scanned at 600dpi. Original magnification 49,500.

Biological Sources
NCBI Organism Classification
Cell Type
glomerular endothelial cell
kidney cell
Biological Context
Biological Process
glomerular filtration
Marilyn G. Farquhar
George E. Palade EM Slide Collection
Digital Object Identifier (DOI)
Archival Resource Key (ARK)
Grouping This image is part of a group.
Sample Preparation
osmium tetroxide fixed tissue
Relation To Intact Cell
sectioned tissue
Spatial Axis Image Size Pixel Size
X 6000px ——
Y 5024px ——