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*CIL – Cell Image Library accession number. Please use this to reference an image.

CIL:37125*  Cite 

Transmission electron micrograph showing capillary mouse myocardium continuous endothelium using a hemoglobin tracer in caveolae. Hemoglobin, used as a tracer, is seen in the lumen of a capillary lined by a continuous endothelium, in endothelial caveolae, and in the extracellular space. Tracers such as hemoglobin or small heme-peptides were used by these investigators to demonstrate the role of caveolae in transcytosis of molecules across continuous capillary endothelial cells. Image made available by James D. Jamieson and the Department of Cell Biology, Yale University School of Medicine.

Technical Details

Reference: Simeonescu, N., M. Simeonescu, and G. E. Palade. 1975. J. Cell Biol. 64:586-607. Original 3.25 in. x 4 in. lantern slides were scanned at 600dpi. Original magnification X84,000.

Biological Sources
NCBI Organism Classification
Mus musculus
Cell Type
endothelial cell
Cellular Component
Biological Context
Biological Process
regulation of vascular permeability
George E. Palade
Maya Simonescu
Nicole SImonescu
George E. Palade EM Slide Collection
Digital Object Identifier (DOI)
Archival Resource Key (ARK)
Grouping This image is part of a group.
Image Type
recorded image
Image Mode
transmission electron microscopy (TEM)
Parameters Imaged
electron density
Source of Contrast
differences in adsorption or binding of stain
Visualization Methods
osmium tetroxide
Sample Preparation
glutaraldehyde fixed tissue
formaldehyde fixed tissue
Graham-Karnosky method
digallic acid
Relation To Intact Cell
sectioned tissue
Spatial Axis Image Size Pixel Size
X 6000px ——
Y 4959px ——