This is one of a group of four images in Figure S5 in Apaja et al., JCB 2010, that support the conclusion that the WT vasopressin type2 receptor (V2R) and the V2R W164S mutant (that causes nephrogenic...

Acid phosphatase is synthesized in the biosynthetic pathway in the ER and packaged in the TGN into primary lysosomes which are passed on to secondary lysosomes. Primary lysosomes are small vesicles of...

The entire membrane of the phagolysosome does appear to have been changed into that similar to the lysosome membrane which bears a thick glycocalyx (polysaccharide coat) and no longer appears to be li...

This is one of six images in Figure 6 in Apaja et al., JCB 2010 that shows the fate of various model membrane proteins, that are either folded or in the unfolded state at the plasma membrane, expresse...

The acidosome-like vesicle has a bull’s eye appearance with the invagination appearing in the middle of the vesicle. Other vesicles contain multiple layers resembling multilipid layers. Two vesicles...

Stimulated Exocytosis. This micrograph shows the peripheral cytoplasm of a mammotroph in the pituitary of a lactating rat. Several secretion granules are lined up facing the perivascular spaces and a...

Cytochalasin B blocks DV release from cytopharynx. In this micrograph a very large nascent vacuole has been retained at the cytopharynx of this cell that had been exposed to cytochalasin B. Many acido...

The acidosome-like vesicle has at least 2 enclosing membranes or one membrane indented back on itself and an internal electron-opaque tongue-like droplet that is continuous with the enclosing membrane...

Acid phosphatase is present in tubules retrieved from late DV-III. The tubules and rounded expansions arising as a result of late DV-III membrane retrieval contain an electron-opaque reaction product ...

This image shows the heterogeneity in the content of lysosomes (Lys) near the plasma membrane between two hepatocytes and near the bile canaliculus (not visible in this field). Some of the lysosomes ...