Expression of transmembrane domain deleted-PINK1-YFP (green) is stabilized in the mitochondira, but does not induce mitochondrial translocation of mCherry-Parkin (red) in PINK1 knock-out mouse embryon...

Expression of R98F PINK1-YFP (green) induces mitochondrial translocation of mCherry-Parkin (red) in the presence of the mitochondrial depolarizing agent CCCP (carbonyl cyanide-m-chlorophenyl hydrazone...

Expression of R98F PINK1-YFP (green), consistent with localization within mitochondria, does not induce mitochondrial translocation of mCherry-Parkin (red). The R98F mutation in PINK1-YFP partially in...

Expression of WT PINK1-YFP (green) does not induce mitochondrial translocation of mCherry-Parkin (red) in PINK1 knock-out mouse embryonic fibroblasts (PINK1 KO MEFs). Transfected PINK1 KO MEFs were tr...

Upon mitochondrial uncoupling, wild-type PINK1-YFP (green) and mCherry-Parkin (red) are localized to mitochondria in PINK1 knock-out mouse embryonic fibroblasts (PINK1 KO MEFs). Transfected PINK1 KO M...

Upon mitochondrial uncoupling, transmembrane domain-deleted PINK1-YFP (green) fails to recruit mCherry-Parkin (red) to mitochondria in PINK1 knock-out mouse embryonic fibroblasts (PINK1 KO MEFs). Tran...

YFP-Parkin (green) does not translocate to mitochondria (red) when HeLa cells are treated with the proteosome inhibitor, MG132. HeLa cells stably expressing YFP-Parkin were treated with MG132 (10µM) ...

YFP-Parkin (green) does not translocate to mitochondria (red) in HeLa cells. HeLa cells stably expressing YFP-Parkin were treated with DMSO for 3 hrs and then stained with TMRE, a cationic fluorescent...

YFP-Parkin (green) does not translocate to mitochondria (red) when HeLa cells are transfected with control siRNA (siCtrl). HeLa cells stably expressing YFP-Parkin were transfected with control siRNA f...

A mutant of the vacuolar proteinase A (ngPrAdelta295-331) (green) is a substrate of ER quality control (ERQC) mechanisms, as determined by the fact that it is retained in the ER (marked by Kar2; red) ...