As with acidosome fusion with the DV-I, lysosome fusion with the DV-II also seems to occur nearly all at once resulting in a phagolysosome (DV-III) with a highly irregular surface. However, unlike the transformation of DV-I into DV-II where the DV-I membrane is removed by immunogold-labeled tubules we have very little immunological evidence that the DV-II membrane is removed during the transition from phagoacidosome to phagolysosome. Although there is some morphological indication for tubular and vesicular formation around these early phagolysosomes that might indicate a similar transformation. The vacuole contents seen here are thought to be the lipid micelles of the axenic medium. TEM taken on 2/27/80 by R. Allen with Hitachi HU11A operating at 75kV. Neg. 7,000X. Bar = 1µm.