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*CIL – Cell Image Library accession number. Please use this to reference an image.

CIL:9778*  Cite 
Description

The proteasome is a large, highly conserved protein complex whose main function is to enzymatically degrade target proteins. The eukaryotic proteasome houses six protease sites that are located deep within the barrel-shaped 20S core particle. Each core particle is built from two outer rings formed from seven alpha subunits, and two inner rings formed from seven beta subunits. The N-termini of the alpha subunit rings on either end of the core particle form a gate which can open to allow passage of target proteins into the proteasome core. This animation shows the structure of the eukaryotic proteasome. The lid structure is approximated from cryo-EM studies, and the core particle and regulatory particle were created using crystal structure data.

Biological Sources
NCBI Organism Classification
Eukaryota
Biological Context
Biological Process
proteasome assembly
Molecular Function
ubiquitin-specific protease activity
Attribution
Names
Janet Iwasa
Alfred Goldberg
David Smith
Link
https://iwasa.hms.harvard.edu/project_pages/p...
Citation
Digital Object Identifier (DOI)
doi:10.7295/W9CIL9778
Archival Resource Key (ARK)
ark:/b7295/w9cil9778
Imaging
Image Type
animation